Lenti-TEM8 CAR (scFv-28εRIγ, SB5)-VP(VP-CAR-LC476)

The ready-to-use lentiviral particles of Lenti-TEM8 CAR (scFv-28εRIγ, SB5)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (SB5)-CD28-FcεRIγ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
TEM8
Expression Cassette
scFv (SB5)-CD28-FcεRIγ
Clone
SB5
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Glioma; breast cancer

Target


Introduction
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
Alternative Names
ATR; GAPO; TEM8; Anthrax toxin receptor 1; ANTR1_HUMAN; ANTXR 1; TEM 8; ATR; FLJ10601; FLJ11298; FLJ21776; Tumor Endothelial Marker 8; Tumor endothelial marker 8 precursor; CD28; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; scFv; SB5
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

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