All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
The vector of anti-c-Met chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human c-Met. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-c-Met antibody linked to 4-1BB and CD3ζ signaling domains. And the vector product was designed for the treatment of Breast cancer.
CAR Construction : Fig.1 SAIT301 pretreatment inhibited the activation of Met and downstream signaling by HGF. HONE1 or HNE1 cells were pretreated with 1 μg/ml SAIT301 for 2 h followed by treatment with 30 ng/ml HGF for 10 min. Cells were harvested and western blot analysis was performed for p-Met, Met (upper band, precursor form of Met (170 kDa); lower band, mature form of Met (145 kDa)), p-ERK, ERK, p-AKT and AKT. α-Tubulin was used as a loading control. |
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