The vector of anti-C2γ and C2ζ chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target mouse C2γ and C2ζ. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-C2γ and C2ζ antibody linked to FcεRIγ signaling domains. And the vector product was designed for the treatment of autoimmune arthritis.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|VP-CAR-LC38||Lenti-C2 CAR (scFv-FcεRIγ, CIIC1; M2139) Viral Particle|
|CAR-T-3-M304-2BZ||Anti-C2 scFv m(CD28-41BB-CD3ζ) CART, pCDCAR1|
|VP-CAR-LC43||Lenti-C2 CAR (scFv-CD4-CD3ζ, CIIC1; M2139) Viral Particle|
|CAR-T-2-M304-BZ||Anti-C2 scFv m(41BB-CD3ζ) CART, pCDCAR1|
|CAR-T-2-M304-4Z||Anti-C2 scFv m(CD4-CD3ζ) CART, pCDCAR1|
|CAR-T-2-M304-CZ||Anti-C2 scFv m(b2c-CD3ζ) CART, pCDCAR1|
|CAR-T-3-M304-2XZ||Anti-C2 scFv m(CD28-OX40-CD3ζ) CART, pCDCAR1|
|CAR-T-1-M304-Z||Anti-C2 scFv m(CD3ζ) CART, pCDCAR1|
|VP-CAR-LC41||Lenti-C2 CAR (scFv-CD28-CD3ζ, CIIC1; M2139) Viral Particle|
|VP-CAR-LC48||Lenti-C2 CAR (scFv-CD28-OX40-CD3ζ, CIIC1; M2139) Viral Particle|
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