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pCDCAR1 G250 h(28), T (CAR-T-1-L404-2)

The vector of anti-G250 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human G250. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-G250 antibody linked to CD28 signaling domains. And the vector product was designed for modifying T lymphocytes, and the modified T lymphocytes was designed for renal carcinoma treatment.

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Details

  • Target
  • Carbonic anhydrase IX (CA9)
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Kidney cancer
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-CD28
  • Discription of Signaling Cassetes
  • CD28
    CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatorysignals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells(APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and 4-1BB. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.

Target

  • Host
  • Humanized
  • Target Species
  • Human
  • Gene Name
  • carbonic anhydrase IX
  • Gene ID
  • 768
  • Synonyms
  • CA9; carbonic anhydrase IX; MN; CAIX; CAIX-expressing metastatic renal cell carcinoma; renal cell carcinoma; RCC; metastatic renal cell carcinoma; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; G250

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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