The vector of anti-MART-1(DMF5) chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human MART-1(DMF5). The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-MART-1(DMF5) antibody linked to CD8 hinge-transmembrane domain and CD3-zeta signaling domains. And the vector product was designed for the treatment of metastatic melanoma.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|TCR-L069||Human anti-MLANA [27–35] T Cell Receptor, pLXSN|
|TCR-L252||Human anti-melan-A T cell receptor (SW-M1-29), pCDTCR1|
|TCR-L068||Murinized (from Human) anti-MLANA (ELAGIGILTV) T Cell Receptor[Cysteine-modiﬁed], pMSGV1|
|VP-CAR-LC333||Lenti-MART-1(DMF5) CAR (scFv-CD28-CD3ζ, Melan-A) Viral Particle|
|VP-TCR-C291||Lenti-MART-1 T cell receptor (5) Viral Particle|
|VP-TCR-C293||Lenti-MART-1 T cell receptor (Codon optimized) (DMF4) Viral Particle|
|TCR-L251||Human anti-melan-A T cell receptor (SW-M1-9), pCDTCR1|
|VP-TCR-C290||Lenti-MART-1 T cell receptor (SIG35α) Viral Particle|
|VP-CAR-LC337||Lenti-MART-1(DMF5) CAR (scFv-41BB-CD3ζ, Melan-A) Viral Particle|
|VP-TCR-C300||Lenti-melan-A T cell receptor (SW-M1-29) Viral Particle|
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