PE-labeled Human Mesothelin CAR Detection Reagent, His Tag (CARD-LX009)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Evaluating CAR expression is an essential step in the production of CAR-T cells. Creative biolabs provides several detection reagents which are uniquely suitable for evaluation of CAR expression. PE-labeled Human Mesothelin CAR Detection Reagent, His Tag is a special detection reagent which carries a polyhistidine tag at the C-terminus, and is used to detect human Mesothelin CAR related to the study of Mesothelioma, ovarian cancer.

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Specifications

Target
Mesothelin

Application
FC

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.

Application Notes
The optimal working dilutions should be determined by the end user.

Diseases
Mesothelioma, ovarian cancer

Molecular Characterization
It contains AA Glu 296 - Gly 580 (Accession # AAH09272.1). It is the PE labeled form of Human Mesothelin (296-580), His Tag.

Conjugation
PE

Tag
His Tag

Size
50 test

Formulation
Lyophilized from 0.22 μm filtered solution in 10 mM Tris, 150 mM NaCl, 0.1% BSA, pH8.2. Normally trehalose is added as protectant before lyophilization.

Expression
Human HEK293 cells

Host Species
Human

Species Reactivity
Human

Form
Lyophilized

Images
Figure 1 Structure

Target

Target Introduction
Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Target Alternative Names
mesothelin

Entrez Gene ID
10232

UniProt ID
AAH09272

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.