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CBL

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This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CQ0118 Anti-CBL (CBXC-0713) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXC-0713 Human scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0119 Anti-CBL (CBXC-0824) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse CBXC-0824 Human scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0120 Anti-CBL (CBXC-3000) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXC-3000 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0121 Anti-CBL (CBXC-0091) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXC-0091 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0122 Anti-CBL (CBXC-2511) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXC-2511 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0123 Anti-CBL (CBXC-0092) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXC-0092 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ3542 Anti-CBL (CBXC-0713) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXC-0713 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ3543 Anti-CBL (CBXC-0824) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse CBXC-0824 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ3544 Anti-CBL (CBXC-3000) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXC-3000 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ3545 Anti-CBL (CBXC-0091) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXC-0091 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ3546 Anti-CBL (CBXC-2511) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXC-2511 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ3547 Anti-CBL (CBXC-0092) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXC-0092 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY2669 Anti-CBL (CBFYC-0883) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBFYC-0883 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY2670 Anti-CBL (CBFYC-0884) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBFYC-0884 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY2671 Anti-CBL (CBFYC-0885) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYC-0885 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY2672 Anti-CBL (CBFYC-0886) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Chicken, Dog, Mouse, Rat CBFYC-0886 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY2673 Anti-CBL (CBFYC-0887) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYC-0887 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5922 Anti-CBL (CBFYC-0883) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBFYC-0883 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5923 Anti-CBL (CBFYC-0884) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBFYC-0884 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5924 Anti-CBL (CBFYC-0885) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYC-0885 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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