HIV-1 gp120

Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope. GP120 is essential for virus entry into cells as it plays a vital role in attachment to specific cell surface receptors. This molecule has specific interaction with the CD4 receptor of helper T cells. Binding to CD4 induces the start of a cascade of conformational changes in gp120 and gp41 that lead to the fusion of the viral with the host cell membrane. Since CD4 receptor binding is the most obvious step in HIV infection, gp120 was among the first targets of HIV vaccine research.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC026 T cell Second PGT145 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC289 T cell Second ~8kb Retroviral CD4-CD28-CD3ζ Human Inquiry
CAR-LC290 T cell Second 17b ~8kb Retroviral CD4-35-scFv-CD28-CD3ζ Human Inquiry
CAR-LC291 T cell Second 17b ~8kb Retroviral CD4-10-scFv-CD28-CD3ζ Human Inquiry
CAR-LC292 T cell Second DDY3 ~8kb Retroviral CD4-35-scFv-CD28-CD3ζ Human Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC528 PGT145 Lentivirus Second scFv (PGT145)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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