OSM

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This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1222-ZP1011 OSM (IL6ST Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human OSM-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1012 OSM (LIFR Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human OSM-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1013 OSM (OSMR Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human OSM-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2411 OSM (IL6ST Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human OSM-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2412 OSM (LIFR Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human OSM-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2413 OSM (OSMR Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human OSM-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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