Tn-MUC1

The MUC1 glycoprotein is a transmembrane epithelial mucin normally expressed on the apical surface of most simple glandular epithelial cells. In tumors, MUC1 is overexpressed and distributed all over the cell surface, aberrantly glycosylated, and shed in the tissue microenvironment. MUC1 expressed by breast cancer carries shortened O-glycans such as GalNAca1-O-Ser/Thr (Tn) or Galh1-3GalNAca1-O-Ser/Thr (T, core 1), which may be sialylated to give sialyl-Tn or sialyl-T. Tn glycoform of MUC1 (Tn-MUC1) is a neoantigen interconnected in various tumors. Hostile to Tn-MUC1 CAR T cells exhibited target-specific cytotoxicity and effectively controlled tumor development in xenograft models of T cell leukemia and pancreatic growth.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC128 T cell Second 237 ~8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC129 T cell Second 237 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC614 237 Lentivirus Second scFv (237)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC615 237 Lentivirus Second scFv (237)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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