VivoCAR™ Anti-c-Met (A1) h(CD28-41BB-CD3z) CAR saRNA (XS-0326-XU29)

Name: VivoCAR™ Anti-c-Met (A1) h(CD28-41BB-CD3z) CAR saRNA
SKU: XS-0326-XU29
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-c-Met (A1) h(CD28-41BB-CD3z) CAR saRNA utilizes a high-efficiency saRNA backbone to express the A1 clone. In the landscape of in vivo CAR-T therapy, the A1 clone is essential for its ability to target the c-Met receptor, which is often upregulated in metastatic solid tumors. The saRNA platform achieves a biological magnification effect, where a minimal dose leads to robust CAR expression, ensuring that reprogrammed T cells can effectively engage and eliminate c-Met positive cells even in the presence of competing HGF ligands.

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CAR Information

Target
c-Met

Target Species
Human

Antibody Clone
A1

scFv Host Species
Human

Receptor Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation CD28-41BB-CD3ζ architecture employs a sequential costimulatory strategy, where the CD28 module drives rapid initial activation and metabolic reprogramming, while the 4-1BB component sustains long-term cellular viability and mitigates exhaustion. This tandem design, anchored by the CD3ζ signaling chain, synergistically amplifies downstream signal transduction, resulting in a balanced T-cell phenotype with robust effector capacity and prolonged durability. The integrated signaling cascade thus optimizes both kinetic expansion and persistence, enhancing antitumor efficacy.

CAR saRNA Properties

Structure
Linear

Cap
Cap 1

PolyA
Segmented PolyA

Product Type
CAR IVT saRNA

Concentration
Lot specific

Buffer
1 mM Sodium Citrate, pH 6.4 (or specialized RNA storage buffer, RNase-free).

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

saRNA Quality Control

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Target Information

Full Name
MET proto-oncogene, receptor tyrosine kinase

Alternative Names
DA11; HGFR; AUTS9; RCCP2; Met; DFNB97

Introduction
c-Met is a receptor tyrosine kinase that, upon binding with Hepatocyte Growth Factor (HGF), regulates cell proliferation, scattering, and invasion.

Targeting Diseases
Non-Small Cell Lung Cancer (NSCLC), Gastric Cancer, Hepatocellular Carcinoma (HCC), Glioblastoma

UniProt ID
P08581

Gene ID
4233

Related Resources

Overview of cMet-Targeted CAR Cell Therapies

Case Studies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.