VivoCAR™ Anti-CD30 (H3.69_V2) h(CD28-41BB-CD3z) CAR saRNA (XS-0326-XU59)

Name: VivoCAR™ Anti-CD30 (H3.69_V2) h(CD28-41BB-CD3z) CAR saRNA
SKU: XS-0326-XU59
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD30 (H3.69_V2) h(CD28-41BB-CD3z) CAR saRNA utilizes the saRNA platform to express the optimized H3.69_V2 clone. In vivo, this clone is highly valued for its superior affinity for CD30-positive Reed-Sternberg cells. The saRNA-driven biological magnification ensures that a minimal initial load leads to powerful, sustained CAR expression, facilitating the thorough in situ depletion of malignant cells in Hodgkin lymphoma while reducing the overall RNA exposure and associated systemic cytokine risks.

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CAR Information

Target
CD30

Target Species
Human

Antibody Clone
H3.69_V2

scFv Host Species
Human

Receptor Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation CD28-41BB-CD3ζ architecture employs a sequential costimulatory strategy, where the CD28 module drives rapid initial activation and metabolic reprogramming, while the 4-1BB component sustains long-term cellular viability and mitigates exhaustion. This tandem design, anchored by the CD3ζ signaling chain, synergistically amplifies downstream signal transduction, resulting in a balanced T-cell phenotype with robust effector capacity and prolonged durability. The integrated signaling cascade thus optimizes both kinetic expansion and persistence, enhancing antitumor efficacy.

CAR saRNA Properties

Structure
Linear

Cap
Cap 1

PolyA
Segmented PolyA

Product Type
CAR IVT saRNA

Concentration
Lot specific

Buffer
1 mM Sodium Citrate, pH 6.4 (or specialized RNA storage buffer, RNase-free).

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

saRNA Quality Control

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Target Information

Full Name
TNF Receptor Superfamily Member 8

Alternative Names
Ki-1; D1S166E; TNFRSF8

Introduction
CD30 is a member of the tumor necrosis factor receptor (TNFR) superfamily. It is a marker of activated B and T cells and is highly expressed in Hodgkin lymphoma and anaplastic large cell lymphoma.

Targeting Diseases
Hodgkin Lymphoma (HL), Anaplastic Large Cell Lymphoma (ALCL), Peripheral T-cell Lymphoma (PTCL)

UniProt ID
P28908

Gene ID
943

Related Resources

Overview of CD30-Targeted CAR Cell Therapies

Case Studies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.