VivoCAR™ Anti-CD72 (Nb.C2) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX130)

Name: VivoCAR™ Anti-CD72 (Nb.C2) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX130
Rating: 5 (1 reviews)

Online Inquiry Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD72 (Nb.C2) h(CD28-41BB-CD3z) CAR circRNA features the Nb.C2 monomeric antigen-recognition domain, which has been optimized for exceptional structural stability and resistance to proteolytic cleavage within the tumor microenvironment. For in-situ immune redirection, this specific clone ensures that transiently reprogrammed T cells maintain rigorous specificity for B-cell leukemia. The circular RNA architecture protects the transcript from enzymatic degradation, providing a steady supply of CAR protein. This offers a safe and repeatable method for targeting CD72-positive lineages, eliminating the risk of insertional mutagenesis while maximizing anti-leukemic efficacy.

Add to Cart

Target Information

Target
CD72

Common Name
CD72

Alternative Names
CD72b, LYB2

Full Name
Cluster of Differentiation 72

Introduction
CD72 is a 45 kDa Type II transmembrane glycoprotein belonging to the C-type lectin family. It is primarily expressed on the surface of B-lineage cells from the pro-B stage through mature B cells, but is downregulated upon differentiation into plasma cells. CD72 functions as a negative regulator of B-cell receptor (BCR) signaling by recruiting SHP-1. Because it is highly expressed in various B-cell malignancies, it serves as a viable alternative or co-target to CD19/CD22, especially in cases of antigen escape or lineage switch.

Targeting Diseases
B-cell Acute Lymphoblastic Leukemia (B-ALL), Chronic Lymphocytic Leukemia (CLL), Mantle Cell Lymphoma (MCL)

UniProt ID
P21854

Gene ID
971

Target Species
Human

Antibody Clone
Nb.C2

scFv-Host Species
Lama pacos

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Customer Reviews and Q&As

There are currently no customer reviews or questions for VivoCAR™ Anti-CD72 (Nb.C2) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX130). Click the button below to contact us or submit your feedback about this product.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-CD72 (Nb.C2) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX130)

Target Information

Customer Reviews and Q&As

Related Products

CAR Cell Products

CAR Viral Particles

CAR Vector Products

CAR Animal Cells

CAR mRNA

CAR circRNA