VivoCAR™ Anti-ERBB2 (C1) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX36)

Name: VivoCAR™ Anti-ERBB2 (C1) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX36
Rating: 5 (1 reviews)

Online Inquiry Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-ERBB2 (C1) h(CD28-41BB-CD3z) CAR circRNA leverages the high-affinity C1 clone for the rapid recognition of HER2 overexpressing lineages in aggressive carcinomas. In the context of in-situ cell engineering, the C1 clone ensures that even a transient surge of CAR expression leads to maximal cytolytic signaling. The stable circRNA scaffold protects the therapeutic payload from degradation, facilitating a steady supply of CAR protein to endogenous lymphocytes. This offers a highly effective and safe alternative for targeting HER2+ gastric and breast cancers without the risk of genomic integration.

Add to Cart

Target Information

Target
ERBB2

Common Name
ERBB2

Alternative Names
NEU, NGL, HER2, TKR1, CD340, HER-2, VSCN2, MLN 19, MLN-19, c-ERB2, c-ERB-2, HER-2/neu, p185(erbB2)

Full Name
erb-b2 Receptor Tyrosine Kinase 2

Introduction
ERBB2 is a member of the ErbB family of receptor tyrosine kinases. It is highly activated in many aggressive cancers due to gene amplification and overexpression, particularly in breast and gastric tumors. Its lack of a known ligand and its role as a preferred dimerization partner for other ErbB receptors make it a critical oncogenic driver and a premier therapeutic target.

Targeting Diseases
Breast Cancer, Gastric Cancer, Ovarian Cancer, Lung Cancer

UniProt ID
P04626

Gene ID
2064

Target Species
Human

Antibody Clone
C1

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Customer Reviews and Q&As

There are currently no customer reviews or questions for VivoCAR™ Anti-ERBB2 (C1) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX36). Click the button below to contact us or submit your feedback about this product.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.