VivoCAR™ Anti-PSMA (A) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX114)

Name: VivoCAR™ Anti-PSMA (A) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX114
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-PSMA (A) h(CD28-41BB-CD3z) CAR circRNA leverages the specialized "A" clone, optimized for its high specificity toward PSMA overexpressed on the neovasculature of various non-prostatic solid tumors. In the realm of in vivo engineering, this clone provides a unique anti-angiogenic strategy. By utilizing the non-viral circRNA platform, the product facilitates a potent redirection of the immune system to "starve" tumors by destroying their vascular support. This transient, non-integrating approach allows for iterative dosing while protecting healthy tissues through the naturally self-limiting life of the RNA transcript.

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Target Information

Target
PSMA

Common Name
PSMA

Alternative Names
PSM, FGCP, FOLH, GCP2, FOLH1, mGCP, GCPII, NAALAD1

Full Name
Prostate-Specific Membrane Antigen

Introduction
PSMA is a Type II transmembrane glycoprotein with enzymatic activity. While expressed at low levels in the prostate, small intestine, and salivary glands, it is highly overexpressed in nearly all stages of prostate cancer, including metastatic castration-resistant prostate cancer (mCRPC). Its expression levels often correlate with tumor grade and progression. Additionally, PSMA is expressed on the neovasculature of many non-prostatic solid tumors, making it a versatile target for CAR T-cell therapy.

Targeting Diseases
Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Renal Cell Carcinoma

UniProt ID
Q04609

Gene ID
2346

Target Species
Human

Antibody Clone
A

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Related Resources

Overview of PSMA-Targeted CAR Cell Therapies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-PSMA (A) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX114)

Target Information

Related Resources

Customer Reviews and Q&As

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Protein

CAR circRNA