VivoCAR™ Anti-PSMA (chv75-2a11) h(CD28-41BB-CD3z) CAR saRNA (XS-0326-XU98)

Name: VivoCAR™ Anti-PSMA (chv75-2a11) h(CD28-41BB-CD3z) CAR saRNA
SKU: XS-0326-XU98
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-PSMA (chv75-2a11) h(CD28-41BB-CD3z) CAR saRNA leverages high-efficiency saRNA to deliver the chv75-2a11 clone. In the landscape of in vivo CAR-T for prostate cancer, this clone is highly valued for its binding to the extracellular domain of PSMA. The biological magnification effect of saRNA ensures that a minimal systemic dose leads to robust CAR expression, enabling T cells to reprogram in situ and effectively target PSMA-positive metastatic lesions even in the presence of soluble PSMA variants.

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CAR Information

Target
PSMA

Target Species
Human

Antibody Clone
chv75-2a11

scFv Host Species
Human

Receptor Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation CD28-41BB-CD3ζ architecture employs a sequential costimulatory strategy, where the CD28 module drives rapid initial activation and metabolic reprogramming, while the 4-1BB component sustains long-term cellular viability and mitigates exhaustion. This tandem design, anchored by the CD3ζ signaling chain, synergistically amplifies downstream signal transduction, resulting in a balanced T-cell phenotype with robust effector capacity and prolonged durability. The integrated signaling cascade thus optimizes both kinetic expansion and persistence, enhancing antitumor efficacy.

CAR saRNA Properties

Structure
Linear

Cap
Cap 1

PolyA
Segmented PolyA

Product Type
CAR IVT saRNA

Concentration
Lot specific

Buffer
1 mM Sodium Citrate, pH 6.4 (or specialized RNA storage buffer, RNase-free).

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

saRNA Quality Control

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Target Information

Full Name
Prostate-Specific Membrane Antigen

Alternative Names
PSM; FGCP; FOLH; GCP2; FOLH1; mGCP; GCPII; NAALAD1

Introduction
PSMA is a type II transmembrane protein that is significantly upregulated in prostate cancer cells and the neovasculature of many solid tumors, making it a premier target for cell-based and radioligand therapies.

Targeting Diseases
Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Renal Cell Carcinoma

UniProt ID
Q04609

Gene ID
2346

Related Resources

Overview of PSMA-Targeted CAR Cell Therapies

Case Studies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.