Creative Biolabs

DSPE-PEG-DMMA

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COA

Cat. No.: TDLD-0126-LD605

DSPE-PEG-DMMA

DSPE-PEG-DMMA is a tumor microenvironment-targeting conjugate. It consists of a DSPE-PEG backbone with a terminal 2,3-Dimethylmaleic Anhydride (DMMA) group. DMMA is an anionizable moiety that confers a charge-reversal property to nanoparticles. It is stable and slightly negative at neutral pH (bloodstream) but hydrolyzes rapidly in the mildly acidic tumor extracellular environment (pH ~6.5-7.0), shedding the DMMA and exposing a positively charged surface. This charge reversal promotes enhanced cellular uptake specifically within tumors. Please note that this product is intended for research purposes only.

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For Research Use Only. Not for Diagnostic or Treatment Applications.
Alternative Name 1,2-distearoyl-sn-glycero-3-phospho-ethanolamine-Polyethyleneglycol-DMMA
Category Stimuli-Responsive Lipids; PEG Derivatives
Lipid Anchors DSPE
Lipid Type Saturated PE
PEG Molecular Weight 1000; 2000; 3400; 5000; 10000
Stimulis pH
Application Stimuli-Responsive Delivery; Targeted Delivery; Bioconjugation
Module Type Functional Group
Function Conjugation
Purity >95%
Form Solid/Powder
Solubility Soluble in organic solvents.
Shipping Ice pack
Storage Store at -20°C
Shelf Life One Year

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Creatibe Biolabs' custom LNP was the only solution that successfully delivered our CRISPR-Cas9 payload across the blood-brain barrier with high efficiency and low toxicity.”

Dr. Evelyn Reed

Postdoctoral Researcher, Leading University

Our siRNA candidate was failing due to off-target toxicity, but Creatibe Biolabs' team rapidly redesigned our LNP using their modular platform, rescuing our preclinical program.”

Ben Carter

Project Manager

Achieving cytosolic delivery of our protein degrader with Creatibe Biolabs' exosome platform was the key to unlocking our candidate's full therapeutic potential.”

Dr. Kenji Tanaka

Principal Scientist, Large Pharma Corp

Our oncology drug's efficacy was limited by poor tumor accumulation. Creatibe Biolabs' peptide-conjugated liposomes provided the precise targeting we needed, dramatically increasing the drug's therapeutic index.”

Dr. Clara Schmidt

Senior Scientist, Oncology Innovations Inc.

We required a delivery system that would only release its payload in the tumor's acidic microenvironment. Creatibe Biolabs' pH-responsive liposomes performed flawlessly, minimizing systemic exposure.”

David Chen

Formulation Scientist

Outstanding expertise in antibody engineering.The team's attention to detail and innovative approaches have sianificantly accelerated our development timeline.

Sarah L.

Senior Research Scientist

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