F3 Pep-LNP

Cat. No.: TDLD-0825-LD102

F3 Pep-LNP

F3 Pep-LNP is a state-of-the-art peptide-functionalized lipid nanoparticle (LNP), designed for efficient targeted delivery of therapeutic cargoes such as siRNA, mRNA, DNA, small molecule drugs, and RNA-guided gene editing systems. Engineered with the F3 peptide, a tumor-targeting peptide derived from High Mobility Group A2 (HMGA2) that exhibits high selectivity for cancer cells, this LNP specifically recognizes and binds to nucleolin, a target highly expressed on the surface of tumor cells and tumor vascular endothelial cells, thereby guiding the complex to accumulate at the tumor site. Our LNP is prepared using DSPE-PEG-F3 and a variety of optional lipid formulations including DLin-MC3-DMA, LP-01, ALC-0315, SM102, and others. These formulations are carefully selected to ensure the LNP has uniform particle size, high encapsulation efficiency, stability, and targeted delivery. Applications of F3 Pep-LNP include enhancing the accumulation of therapeutic agents specifically within the tumor microenvironment, developing targeted tumor imaging probes, studying the biology of nucleolin in tumor growth and angiogenesis, and evaluating novel strategies for selective cancer therapy. Please note that this product is intended for research purposes only.