Creative Biolabs has developed a new platform of switchable CAR by using a peptide neo-epitope (PNE) in the switch molecule. In this platform, the switch molecule contains a peptide of 14-aa residues. This 14-aa PNE tag can be specifically recognized by the signaling CAR containing a PNE-specific scFv . This 14-aa PNE is found in the yeast transcription factor GCN4 and was genetically inserted at the defined site of a tumor antigen targeted scFv. The 14-aa PNE of yeast GCN4 does not exist in the human body.
Creative Biolabs provides customized Anti-PNE(GCN4) CAR design and construction services. Please contact us for more detailed information.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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