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A ZipCAR [BZip-BBζ], with a CAR Adaptor [Anti-BCMA Antibody scFv(25D2)-AZip], a SUPRA CAR System (CAR-NR-ZP510)

The split, universal, and programmable (SUPRA) CAR system is a two-component receptor system consisting of a universal receptor with leucine zipper adaptor (zipCAR) on T cells and a separate scFv with leucine zipper adaptor (zipFv) molecule targeting specific antigens. This split "lock-key" structure of SUPRA CAR with leucine zipper adaptors was desighed to enhance the flexibility and controllability of CARs, which has several clinically relevant advantages over a rigid CAR system:

• Antigen targets of one set of zipCAR T cells can be switched, expanded and combined without further modification of the CAR T cells.
• The activities and toxicities of SUPRA CAR T cells can be controlled and fine-tuned.
• Signaling domains and effector cell types can be changed and combined.

Creative Biolabs provides customized SUPRA design and construction services. Please contact us for more detailed information.

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CAR Schemeitc

UniCAR

  • CAR Construction
  • BZip-41BB-CD3ζ
  • Discription of Signaling Cassetes
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigennonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric 4-1BB and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
  • Vector Name
  • pCDCAR1
  • Vector length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Targeting Diseases
  • Multiple Myeloma

CAR Adaptor

  • Adaptor Target
  • BCMA
  • Common Name
  • TNFRSF17
  • Adaptor Type
  • ScFv Antibody
  • Antibody Host
  • Humanized
  • Antibody Clone
  • 25D2
  • CAR Adaptor Tag
  • AZip

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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