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Anti-ACAN T cell receptor ((5/4E8)-1), pCDTCR1 (TCR-YC0059)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

5/4E8-TCR-Tg BALB/c mice are transgenic for a Vβ4/Vα1.1 TCR specific for the immunodominant CD4 T-cell epitope of human aggrecan, p89-103 (ATEGRVRVNSAYQDK).

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Details

  • Target
  • ACAN
  • Target Species
  • Human
  • Epitope
  • ATEGRVRVNSAYQDK
  • Format
  • Non-Modified TCR
  • Allele
  • H2-IAd
  • Targeting Diseases
  • Skeletal dysplasia
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • 5/4E8
  • Host Species
  • Mouse

Target

  • Introduction
  • This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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