Anti-CDH2 DNA-encoded mAb (DMAb), pVAX1 (DMAb-0380-CQ)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-CDH2 DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
CDH2

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
1000

UniProt ID
P19022

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-0381-CQ	CDH2/1573	Mouse		IgG1, κ	A human partial recombinant protein corresponding to the intracellular portion of CDH2
DMAb-0358-WJ	13A9	Mouse		IgG1	Cytoplasmic domain of human N Cadherin.
DMAb-0359-WJ	8C11	Mouse		IgG1	Bacterial fusion protein corresponding to the extracellular domain of N-cadherin
DMAb-0363-WJ	1C5	Mouse	Human	IgG1	The extracellular domain of human CDH2 (NP_001783) produced in human cells
DMAb-0364-WJ	2G7	Mouse		IgG2a
DMAb-0366-WJ	3B9	Mouse		IgG1, κ	Recombinant domain corresponding to the intracellular domain of chicken N-Cadherin
DMAb-0367-WJ	3G48	Rat		IgG2a	Neuronal tissue of chick embryos
DMAb-0368-WJ	5D5	Mouse		IgG1	Purified recombinant fragment of human CDH2 expressed in E. Coli
DMAb-0370-WJ	D4R1H	Rabbit	Human
DMAb-0371-WJ	FA-5	Mouse	Chicken	IgG1
DMAb-0372-WJ	GC-4	Mouse		IgG1	Recombinant full length protein (Chicken heart)
DMAb-0373-WJ	M170	Mouse		IgG1
DMAb-0375-WJ	NCD-2	Rat		IgG2a	Neuronal tissue of chick embryos

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-CDH2 DNA-encoded mAb (DMAb), pVAX1 (DMAb-0380-CQ)

Specifications

Target

Customer Reviews and Q&As

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