Anti-CMV pp65 (JG-9) TCR (HLA-A*0201/NLVPMVATV) Lentivirus Packaging Kit (XS-0622-YF186)

Name: Anti-CMV pp65 (JG-9) TCR (HLA-A*0201/NLVPMVATV) Lentivirus Packaging Kit
SKU: XS-0622-YF186
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This kit provides a complete lentivirus packaging system to produce anti-pp65 (JG-9) TCR lentivirus, which enables TCR-T cells generation to target pp65. It contains plasmids that express all the viral proteins necessary, and TCR detection reagent, providing a full set of reagents for TCR lentivirus packaging and TCR expression evaluation. The expressed anti-pp65 TCR lentiviruses are HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells. These viruses constitutively express the TCR restricted to HLA-A*0201/NLVPMVATV(495-503). TCR detection reagent can be used to detect the positive expression rate of TCR-T cells after lentiviral transduction.

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Description

Target
pp65

Components
This kit contains a TCR lentiviral vector, packaging vectors, TCR detection reagent, and 293 cells.
1. A TCR lentiviral vector
• Anti-pp65 (JG-9) TCR plasmid
2. Three packaging vectors
• LentiArt™ pHelp1
• LentiArt™ pHelp2
• LentiArt™ pHelp3
3. TCR detection reagent
4. 293 cells

Size
10 reactions; 20 reactions; 50 reactions

Storage Conditions
For details of the storage requirements, please see the User Manual for instructions.

Applications
TCR lentivirus packaging; TCR lentivirus transfection; TCR-T cell development; TCR-T cell therapy.

TCR Vector

MHC Allele
HLA-A*0201

Peptide
NLVPMVATV

Epitope
495-503

Vector Name
pCDCAR1

Vector Length
~8kb

Vector Type
Lentiviral vector

TCR Construction
TCR alpha-P2A-TCR beta

Target

Gene Name
UL83

Full Name
pp65

scFv
JG-9

Host Species
Human

Target Species
CMV

Uniprot ID
P06725

Target Background
Cytomegalovirus (CMV) is a member of the herpes virus group which includes herpes simplex virus types 1 and 2; Varicella Zoster Virus, which causes chicken pox; and Epstein Barr virus, which causes infectious mononucleosis. These viruses remain dormant within the body over a long period. In humans, CMV is known as HCMV or human herpesvirus 5 (HHV-5). HHV-5 causes only a brief mononeucleosis-like malaise in immunocompetent adults, but may cause severe illness or death in immunosuppressed individuals. CMV pp65 is the early-late lower matrix phosphoprotein of CMV that may be relevant to the etiopathogenesis of scleroderma. CMV pp65 is a major constituent of the CMV virion bodies and is abundantly synthesized during lytic infection. In addition, the CMV pp65 protein is a frequent target for the exceptionally strong CMV-specific CD8(+) T cell response.

Synonyms
65 kDa phosphoprotein; pp65; 65 kDa matrix phosphoprotein; Phosphoprotein UL83; Tegument protein UL83;
UL83

Related Disease
Cytomegalovirus infection

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-CMV pp65 (JG-9) TCR (HLA-A*0201/NLVPMVATV) Lentivirus Packaging Kit (XS-0622-YF186)

Description

TCR Vector

Target

Customer Reviews and Q&As

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