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Anti-Env Precursor T cell receptor (EF4.1), pCDTCR1 (TCR-YC0359)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-Env Precursor T cell receptor (TCR) is constructed for the engineering of T cell to target Envelope glycoprotein precursor (DEPLTSLTPRCNTAWNRLKL) restricted by H2-IAᵇ. The T cells are genetically modified through transduction with a lentiviral vector expressing Env Precursor-specific T cell receptor.

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Details

  • Target
  • Env Precursor
  • Target Species
  • MuLV
  • Epitope
  • DEPLTSLTPRCNTAWNRLKL
  • Format
  • Non-Modified TCR
  • Allele
  • H2-IAᵇ
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • EF4.1
  • Host Species
  • Mouse

Target

  • Introduction
  • The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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