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Anti-GCK152 T cell receptor (Vα24Vβ11), pCDTCR1 (TCR-YC0426)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-GCK152 T cell receptor (TCR) is constructed for the engineering of T cell to target GCK152 restricted by human CD1d. The T cells are genetically modified through transduction with a lentiviral vector expressing GCK152-specific T cell receptor.

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Details

  • Target
  • GCK152
  • Epitope
  • GCK152
  • Format
  • Non-Modified TCR
  • Allele
  • human CD1d
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • Vα24Vβ11
  • Host Species
  • Human

Target

  • Introduction
  • GCK127 and GCK152 have their O-glycosidic linkages replaced with an E-alkene linker between the sugar and lipid moieties, reminiscent of C-glycoside (-C-GalCer), whereas GCK152 also has a truncated fatty acid with a terminal phenyl group. Naphthylcarba-GalCer (NC-GC) has an aromatic 6_x0007_-OH galactose modification, similar to the previously crystallized naphthylurea (NU)-GC. However, unlike NU-GC where the naphthyl is linked via a urea group, NC-GC has a carbamate linker, which provides more flexibility to the naphthyl moiety.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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