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Anti-PB1 T cell receptor (3016), pCDTCR1 (TCR-YC0840)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-PB1 T cell receptor (TCR) is constructed for the engineering of T cell to target RNA-directed RNA polymerase catalytic subunit (SSYRRPVGI) restricted by H2-Kᵇ. The T cells are genetically modified through transduction with a lentiviral vector expressing PB1-specific T cell receptor.

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Details

  • Target
  • PB1
  • Target Species
  • IAV
  • Epitope
  • SSYRRPVGI
  • Format
  • Non-Modified TCR
  • Allele
  • H2-Kᵇ
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • 3016
  • Host Species
  • Mouse

Target

  • Introduction
  • RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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