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Anti-Human CD171 (XW-597)-BBZ CAR, pCARIVT (XS-0822-YF597)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The IVT vector of anti-CD171 scFv (XW-597)-BBZ chimeric antigen receptor (CAR) is constructed for the CAR mRNA production. The CAR components consist of scFv of anti-CD171 antibody linked to 4-1BB (CD137) and CD3ζ signaling domains. The IVT components consist of T7 promoter-5' UTR-Kozak-CAR-Stop-3' UTR-PolyA.

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Details

  • Target
  • CD171
  • Targeting Diseases
  • Ovarian cancer
  • Generation
  • Second
  • Vector Name
  • pCARIVT
  • Vector Type
  • In Vitro Transcription (IVT) Vector
  • Key IVT Component
  • T7 promoter-5' UTR-Kozak-CAR-Stop-3' UTR-PolyA
  • Receptor Construction
  • scFv-41BB-CD3ζ
  • Discription of Signaling Cassetes
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigen-nonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

Target

  • Clone
  • XW-597
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • L1CAM
  • Synonyms
  • L1CAM
  • Introduction
  • The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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