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Anti-Human CLEC12A (1075.7) h(41BB-CD3Z) CAR Lentivirus Packaging Kit (XS-0622-YF31)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This kit provides a complete lentivirus packaging system to produce anti-CLEC12A (1075.7) h(4-1BB-CD3ζ) CAR lentivirus, which enables CAR-T cells generation to target Human CLEC12A. It contains plasmids that express all the viral proteins necessary, and CAR detection reagent, providing a full set of reagents for CAR lentivirus packaging and CAR expression evaluation. The expressed anti-CLEC12A CAR lentiviruses are HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells. These viruses constitutively express the scFv portion of anti-CLEC12A (1075.7) linked to 2nd generation CAR containing 4-1BB and CD3ζ signaling domains. CAR detection reagent can be used to detect the positive expression rate of CAR-T cells after lentiviral transduction.

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Description

  • Target
  • CLEC12A
  • Components
  • This kit contains a CAR lentiviral vector, packaging vectors, CAR detection reagent, and 293 cells.
    1. A CAR lentiviral vector
    • Anti-CLEC12A (1075.7) h(41BB-CD3ζ) CAR
    2. Three packaging vectors
    • LentiArt™ pHelp1
    • LentiArt™ pHelp2
    • LentiArt™ pHelp3
    3. CAR detection reagent
    4. 293 cells
  • Size
  • 10 reactions; 20 reactions; 50 reactions
  • Storage Conditions
  • For details of the storage requirements, please see the User Manual for instructions.
  • Applications
  • CAR lentivirus packaging; CAR lentivirus transfection; CAR-T cell development; CAR-T cell therapy.

CAR Vector

  • CAR Generation
  • 2nd-generation CAR
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • scFv-41BB-CD3ζ

Target

  • Gene Name
  • CLEC12A
  • Full Name
  • C-type lectin domain family 12 member A
  • scFv
  • 1075.7
  • Host Species
  • Mouse
  • Target Species
  • Human
  • Target Background
  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.
  • Synonyms
  • CLEC12A, MICL, CLL-1, CLL1, DCAL2, DCAL-2, CD371
  • Related Disease
  • Acute myeloid leukemia (AML)

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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