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Anti-KAT6A T cell receptor, pCDTCR1 (TCR-ZP511)

The vector of anti-KAT6A T cell receptor (TCR) is constructed for the engineering of T cell to target HCV. The T cells are genetically modified through transduction with a lentiviral vector expressing KAT6A-specific T cell receptor. And the vector product was designed for the treatment of Breast cancer.

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Details

  • Target
  • KAT6A
  • Target Species
  • HCV
  • Epitope
  • KLSREIMPV
  • Format
  • Non-modified
  • HLA
  • HLA-DRB5
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Breast cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • JB11
  • TCR Host Animal
  • Human

Target

  • Introduction
  • This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl transferase domain, a glutamate/aspartate rich region, and a serine and methionine rich transactivation domain. It is part of a complex that acetylates lysine 9 residues in histone 3, and in addition, it acts as a co activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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