Anti-MFGE8 DNA-encoded mAb (DMAb), pVAX1 (DMAb-2213-FY)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-MFGE8 DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
MFGE8

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
4240

UniProt ID
Q08431

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-2213-FY	CBFYM-0104	Mouse	Human	IgG2a	Mouse myeloma cell line NS0-derived recombinant human MFG-E8, Leu24-Cys387
DMAb-2214-FY	CBFYM-0274	Mouse	Human	IgG1, k	Delipidated human milk fat globule membrane preparation.ImmunogenType: Membrane fraction
DMAb-2215-FY	CBFYM-0628	Mouse	Human	IgG1
DMAb-2216-FY	CBFYM-0629	Mouse	Human	IgG1, k
DMAb-2217-FY	CBFYM-2143	Mouse	Human	IgG2b
DMAb-2218-FY	CBFYM-2144	Mouse	Human	IgG2a	Mouse myeloma cell line NS0-derived recombinant human MFG-E8, Leu24-Cys387
DMAb-2219-FY	CBFYM-2145	Mouse	Human	IgG2a, k	Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: YAGNHCETKC VEPLGMENGN IANSQIAASS VRVTFLGLQH WVPELARLNR AGMVNAWTPS SNDDNPWIQV NLLRRMWVTG VVTQGASRLA SHEYLKAFKV AYSLNGHEFD
DMAb-2220-FY	CBFYM-2146	Mouse	Human	IgG1	HMFG Membrane tissue/cell preparation
DMAb-2221-FY	CBFYM-2147	Mouse	Human	IgG2b	Recombinant Human MFGE8 protein
DMAb-2222-FY	CBFYM-2148	Mouse	Human	IgG1, k	Recognizes a protein of 40-45kDa, identified as human milk fat globule membrane protein (HMFG)
DMAb-2223-FY	CBFYM-2149	Hamster	Mouse	IgG	Recombinant mouse MFG-E8
DMAb-2224-FY	CBFYM-2150	Hamster	Mouse	IgG	Thioglycollate-elicited mouse peritoneal macrophages
DMAb-2225-FY	CBFYM-2151	Rat	Mouse	IgG2a	Mouse myeloma cell line NS0-derived recombinant mouse MFG-E8 Ala23-Cys463
DMAb-0011-YJ	EDM45	Mouse	Human	IgG1, κ	A delipidated human milk fat globule membrane preparation was used as the immunogen for the Lactadherin antibody.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-MFGE8 DNA-encoded mAb (DMAb), pVAX1 (DMAb-2213-FY)

Specifications

Target

Customer Reviews and Q&As

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