pCDCAR1 CD19 h(DAP10ζ) (CAR-MZ127)

The vector of anti-CD19 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD19. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-CD19 antibody linked to DAP10 and CD3ζ signaling domains. And the vector product was designed for the treatment of Acute lymphoblastic leukemia .

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  • Target
  • CD19
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Acute lymphoblastic leukemia
  • Generation
  • Second
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Retroviral
  • Receptor Construction
  • scFv-DAP10-CD3ζ
  • Discription of Signaling Cassetes
  • DAP10
    DNAX-activating protein 10 (DAP10) is a transmembrane adaptor protein for natural killer group 2, member D (NKG2D), directly binds to RAGE and modulates the S100A8/A9-triggered signaling pathway. DAP10 as well as S100A8/A9 and RAGE were overexpressed in psoriatic epidermis.
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.


  • Clone
  • SJ25C1
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • CD19 Molecule
  • Synonyms
  • CD19; B4; CVID3; MGC12802

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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