CellRapeutics™ CD19⁺ B Cells from Type 2 Diabetes Donor (XS-0426-XU8)

Name: CellRapeutics™ CD19+ B Cells from Type 2 Diabetes Donor
SKU: XS-0426-XU8
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Isolated from donors with metabolic syndrome and insulin resistance, these B cells are specialized for the study of "immunometabolism." Unlike autoimmune variants, these cells allow researchers to examine how chronic low-grade systemic inflammation and hyperglycemia modulate B cell effector functions and their contribution to the metabolic pro-inflammatory milieu.

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Donor Information

Product Name
CellRapeutics™ CD19⁺ B Cells from Type 2 Diabetes Donor

Cat. No.
XS-0426-XU8

Donor Age
Middle-Aged, Senior

Donor Health
Diagnosed with Type 2 Diabetes Mellitus (T2DM). Donors exhibit chronic metabolic dysfunction, insulin resistance profiles, and associated low-grade systemic inflammation.

Ethnicity
Diverse backgrounds available.

Anticoagulant
Heparin, preferred to minimize glucose-related metabolic shifts and oxidative stress during leukapheresis, ensuring stable B-cell bioenergetics despite donor hyperglycemia.

Additional Donor Information
Each lot features CD19⁺ B cells from donors with Type 2 Diabetes. Profiles include BMI, HbA1c levels, and metabolic history, allowing for the study of chronic inflammation and metabolic influence on B-cell function.

Clinical Profile
Glycemic control history, duration of disease, Body Mass Index, and presence of diabetic complications.

Additional Information

Medication History
Available upon request. Includes long-term history of oral hypoglycemic agents, GLP-1 receptor agonists, and exogenous insulin use.

Formulation
Cryopreserved in specialized freezing medium

Cell Purity
>90%

Cell Viability
>90%

Mycoplasma Testing
Negative

Sterility Testing
Negative

Genetic Stability Testing
The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.

Application
Drug Discovery, Immuno-oncology Research

Research Use Only
RUO

Quality Control
Each product batch undergoes rigorous testing for purity, viability, and microbial contamination.

Storage
Upon arrival, immediately transfer the vial to the liquid nitrogen.

Shiping
Dry Ice

Handling Notes
Upon thawing, it is recommended to rapidly thaw the cells in a 37°C water bath, followed by the slow addition of pre-warmed culture medium to minimize osmotic shock.

Warnings
Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.

Size
1E7 cells/vial, 2.5E7 cells/vial

Keywords
CellRapeutics™ CD19⁺ B Cells from Type 2 Diabetes Donor, CD19⁺ B Cells, Type 2 Diabetes

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.