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CellRapeutics™ CD3+ T Cells from Scleroderma Donor (XS-0426-XU219)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

These CD3+ T cells are isolated from donors afflicted with Systemic Sclerosis, providing access to the immune cells that drive tissue fibrosis and vasculopathy. The cell population is enriched with subsets involved in the profibrotic crosstalk with fibroblasts, specifically via the secretion of IL-4 and IL-13. This product is a vital tool for analyzing the immunological triggers of excessive extracellular matrix deposition and microvascular injury.

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Donor Information

  • Product Name
  • CellRapeutics™ CD3+ T Cells from Scleroderma Donor
  • Cat. No.
  • XS-0426-XU219
  • Donor Age
  • Middle-Aged
  • Donor Health
  • T cells exhibit a pro-fibrotic profile, reflecting their role in orchestrating fibroblast activation and their contribution to the systemic fibrotic microenvironment.
  • Ethnicity
  • Diverse backgrounds available, predominantly African American and Hispanic cohorts.
  • Anticoagulant
  • Acid Citrate Dextrose, tailored to handle microvascular-related coagulation imbalances and protect T-cell viability against the fibrotic inflammatory milieu.
  • Additional Donor Information
  • Each lot features CD3+ T cells from donors with systemic sclerosis. Profiles focus on the T-cell role in skin and lung fibrosis, including relevant cytokine secretion profiles.
  • Clinical Profile
  • Skin involvement extent, presence of interstitial lung disease, and duration of symptoms.

Additional Information

  • Medication History
  • Available upon request. Documentation of systemic immunosuppression and medications for vascular and fibrotic complications affecting T-cell profiles.
  • Formulation
  • Cryopreserved in specialized freezing medium
  • Cell Purity
  • >90%
  • Cell Viability
  • >90%
  • Mycoplasma Testing
  • Negative
  • Sterility Testing
  • Negative
  • Genetic Stability Testing
  • The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.
  • Application
  • Drug Discovery, Immuno-oncology Research
  • Research Use Only
  • RUO
  • Quality Control
  • Each product batch undergoes rigorous testing for purity, viability, and microbial contamination.
  • Storage
  • Store in liquid nitrogen vapor phase for long-term stability, maintain constant temperatures below -150°C to prevent loss of viability.
  • Shiping
  • Dry Ice
  • Handling Notes
  • Perform rapid thawing in a 37°C water bath and dilute slowly with pre-warmed media to ensure optimal cell recovery and function.
  • Warnings
  • Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.
  • Size
  • 2.5E7 cells/vial, 5E7 cells/vial
  • Keywords
  • CellRapeutics™ CD3+ T Cells from Scleroderma Donor, CD3+ T Cells, Scleroderma

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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