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CellRapeutics™ CD3+ T Cells from Type 2 Diabetes Donor (XS-0426-XU223)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

These CD3+ T cells are isolated from donors with Type 2 Diabetes (T2DM), capturing the cellular components of "metainflammation." The T-cell population reflects the chronic metabolic stress of the donor, often characterized by a shift toward proinflammatory Th1 or Th17 phenotypes associated with insulin resistance. They are an essential resource for studying how systemic hyperglycemia and dyslipidemia modulate T-cell effector functions and contribute to diabetic complications.

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Donor Information

  • Product Name
  • CellRapeutics™ CD3+ T Cells from Type 2 Diabetes Donor
  • Cat. No.
  • XS-0426-XU223
  • Donor Age
  • Middle-Aged, Senior
  • Donor Health
  • T cells exhibit signs of "inflammaging," marked by chronic low-grade activation and metabolic exhaustion markers resulting from a sustained hyperinsulinemic and pro-inflammatory metabolic environment.
  • Ethnicity
  • Diverse backgrounds available.
  • Anticoagulant
  • Heparin, preferred to reduce the impact of advanced glycation end-products and hyperlipidemic plasma on T-cell mitochondrial function and long-term viability.
  • Additional Donor Information
  • Each lot features CD3+ T cells from T2DM donors. Profiles focus on the metabolic state of T cells in the context of chronic hyperglycemia and obesity.
  • Clinical Profile
  • BMI, presence of metabolic syndrome components, and history of diabetic complications.

Additional Information

  • Medication History
  • Available upon request. Records of hypoglycemic agents and documentation of treatments for chronic systemic inflammation related to metabolic syndrome.
  • Formulation
  • Cryopreserved in specialized freezing medium
  • Cell Purity
  • >90%
  • Cell Viability
  • >90%
  • Mycoplasma Testing
  • Negative
  • Sterility Testing
  • Negative
  • Genetic Stability Testing
  • The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.
  • Application
  • Drug Discovery, Immuno-oncology Research
  • Research Use Only
  • RUO
  • Quality Control
  • Each product batch undergoes rigorous testing for purity, viability, and microbial contamination.
  • Storage
  • Store in liquid nitrogen vapor phase for long-term stability, maintain constant temperatures below -150°C to prevent loss of viability.
  • Shiping
  • Dry Ice
  • Handling Notes
  • Perform rapid thawing in a 37°C water bath and dilute slowly with pre-warmed media to ensure optimal cell recovery and function.
  • Warnings
  • Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.
  • Size
  • 2.5E7 cells/vial, 5E7 cells/vial
  • Keywords
  • CellRapeutics™ CD3+ T Cells from Type 2 Diabetes Donor, CD3+ T Cells, Type 2 Diabetes

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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