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CellRapeutics™ CD56+ NK Cells from Crohn's Disease Donor (XS-0426-XU295)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Isolated from donors with active Crohn's Disease, these CD56+ NK cells reflect the systemic innate immune dysregulation associated with transmural gastrointestinal inflammation. The cells are captured in a state that reflects the proinflammatory cytokine milieu characteristic of IBD. This product is optimized for investigating the crosstalk between NK cells and enteric myofibroblasts and the role of regulatory NK subsets in maintaining mucosal homeostasis.

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Donor Information

  • Product Name
  • CellRapeutics™ CD56+ NK Cells from Crohn's Disease Donor
  • Cat. No.
  • XS-0426-XU295
  • Donor Age
  • Young Adult
  • Donor Health
  • NK cells reflect a chronic transmural inflammatory environment. They exhibit enhanced secretion of Th1-type cytokines and a skewed repertoire of activating receptors involved in the persistent innate immune response of the gastrointestinal tract.
  • Ethnicity
  • Diverse backgrounds available.
  • Anticoagulant
  • Heparin or Acid Citrate Dextrose, optimized to neutralize pro-inflammatory cytokine interference and maintain NK cell cytolytic potential amidst systemic bowel inflammation.
  • Additional Donor Information
  • Each lot features CD56+ NK cells from donors with Crohn's Disease. Profiles include disease location and current medication, facilitating research into NK-cell derived cytokines in gut inflammation.
  • Clinical Profile
  • Disease phenotype, Harvey-Bradshaw Index, and history of monoclonal antibody therapy.

Additional Information

  • Medication History
  • Available upon request. Documentation of aminosalicylates, corticosteroids, and exposure to biological agents that may modulate NK cell cytokine production or homing.
  • Formulation
  • Cryopreserved in specialized freezing medium
  • Cell Purity
  • >90%
  • Cell Viability
  • >90%
  • Mycoplasma Testing
  • Negative
  • Sterility Testing
  • Negative
  • Genetic Stability Testing
  • The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.
  • Application
  • Drug Discovery, Immuno-oncology Research
  • Research Use Only
  • RUO
  • Quality Control
  • Each product batch undergoes rigorous testing for purity, viability, and microbial contamination.
  • Storage
  • Maintain long-term storage in liquid nitrogen vapor phase (below -150°C), avoid temperature fluctuations above -135°C to preserve NK cell lytic activity.
  • Shiping
  • Dry Ice
  • Handling Notes
  • Perform rapid thawing at 37°C and implement slow, dropwise dilution with pre-warmed media to minimize osmotic stress and ensure optimal cell recovery.
  • Warnings
  • Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.
  • Size
  • 5E6 cells/vial, 1E7 cells/vial
  • Keywords
  • CellRapeutics™ CD56+ NK Cells from Crohn's Disease Donor, CD56+ NK Cells, Crohn's Disease

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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