CellRapeutics™ Leukopak from Ankylosing Spondylitis Donor (XS-0426-XU269)

Name: CellRapeutics™ Leukopak from Ankylosing Spondylitis Donor
SKU: XS-0426-XU269
Rating: 5 (1 reviews)

Online Inquiry Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This Leukopak is sourced from donors diagnosed with Ankylosing Spondylitis, typically associated with the HLA-B27 genotype. The leucocyte repertoire highlights the IL-23/IL-17 axis, featuring elevated frequencies of Th17 and innate-like lymphocytes involved in enthesitis and axial spondyloarthritis. This collection is ideal for research focusing on the genetic and immunological drivers of pathological bone formation and the systemic inflammatory burden of the axial skeleton.

Specific Inquiry

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Donor Information

Product Name
CellRapeutics™ Leukopak from Ankylosing Spondylitis Donor

Cat. No.
XS-0426-XU269

Donor Age
Young Adult

Donor Health
Diagnosed with AS. The immune profile is characterized by Th17-driven systemic inflammation and signatures of leukocyte activity involved in axial skeletal remodeling.

Ethnicity
Primarily Caucasian and East Asian.

Anticoagulant
Acid Citrate Dextrose, optimized to stabilize HLA-B27 associated immune profiles and maintain Th17 cell viability.

Additional Donor Information
Each lot features a Leukopak from donors with AS. Profiles include HLA-B27 status and radiographic evidence of sacroiliitis, supporting studies on the Th17 pathway in spondyloarthritis.

Clinical Profile
HLA-B27 status, BASDAI score, radiographic evidence of sacroiliitis, and history of NSAID or biologic therapy.

Additional Information

Medication History
Available upon request. Records of chronic NSAID use, conventional DMARDs, and exposure to biological therapies.

Formulation
Cryopreserved or Fresh options available.

Cell Purity
>90%

Cell Viability
>90%

Mycoplasma Testing
Negative

Sterility Testing
Negative

Genetic Stability Testing
The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.

Application
Drug Discovery, Immuno-oncology Research

Research Use Only
RUO

Quality Control
Each product batch is strictly validated for high cellular viability, specific immune cell counts, and pathogen-free safety, ensuring consistent clinical phenotypes and ethical compliance for advanced immunological research.

Storage
Store fresh Leukopaks at 2°C to 8°C for immediate use, cryopreserved samples must be kept in liquid nitrogen vapor phase below -150°C.

Shiping
Dry Ice

Handling Notes
Process fresh cells within 48 hours or perform rapid thawing of cryovials in a 37°C water bath followed by gradual dilution to maximize recovery.

Warnings
Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.

Size
Full Bag, Half Bag

Keywords
CellRapeutics™ Leukopak from Ankylosing Spondylitis Donor, Leukopak, Ankylosing Spondylitis

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.