Lenti-CD22 CAR (scFv-CD8ζ, FMC63)-VP(VP-CAR-LC80)
The ready-to-use lentiviral particles of Lenti-CD22 CAR (scFv-CD8ζ, FMC63)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (FMC63)-CD8-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.
Specifications
Type of Therapeutics
Chimeric Antigen Receptor
Expression Cassette
scFv (FMC63)-CD8-CD3ζ
Packaging System
Lentivirus
Targeting Diseases
Acute lymphoblastic leukemia (ALL)
Target
Introduction
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
Alternative Names
CD22; CD22 molecule; SIGLEC2; SIGLEC-2; acute lymphoblastic leukemia; leukemia; ALL; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; FMC63
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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Leukemia
Kits for CARs/TCRs Development 
Datasheet
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