The vector of anti-mesothelin chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human mesothelin. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-mesothelin antibody linked to KIR2DS2, and another vector expresssing DAP12 signaling domain. When introduced into human T cells with DAP12, the KIR-based CAR triggers enhanced antigen-specific proliferation and anti-tumor activity. And the vector product was designed for the treatment of pancreatic cancer, ovarian cancer, lung cancer, malignant pleural mesothelioma tumors (MPM tumors).
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|CAR-LC069||Anti-Mesothelin (M4) h(41BB-CD3ζ) CAR, pCDCAR1|
|CAR-LC086||Anti-Mesothelin (M21) h(41BB-CD3ζ) CAR, pCDCAR1|
|VP-CAR-LC565||Lenti-Mesothelin CAR (scFv-41BB-CD3ζ, M11) Viral Particle|
|CAR-LC268||Anti-MSLN (HN1) h(41BB/CD3ζ, FKBP/FRB) Conditional CAR, pCDCAR1|
|CAR-LC023||Anti-Mesothelin (m912) h(CD3ζ) CAR, pCDCAR1|
|CAR-LC089||Anti-Mesothelin (M24) h(41BB-CD3ζ) CAR, pCDCAR1|
|CAR-T-2-M321-2Z||Anti-mesothelin scFv h(CD28-CD3ζ) CART, pCDCAR1|
|CAR-LC071||Anti-Mesothelin (M6) h(41BB-CD3ζ) CAR, pCDCAR1|
|CAR-LC072||Anti-Mesothelin (M7) h(41BB-CD3ζ) CAR, pCDCAR1|
|VP-CAR-LC576||Lenti-Mesothelin CAR (scFv-41BB-CD3ζ, M22) Viral Particle|
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