The vector of anti-mesothelin chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human mesothelin. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-mesothelin antibody linked to KIR2DS2, and another vector expresssing DAP12 signaling domain. When introduced into human T cells with DAP12, the KIR-based CAR triggers enhanced antigen-specific proliferation and anti-tumor activity. And the vector product was designed for the treatment of pancreatic cancer, ovarian cancer, lung cancer, malignant pleural mesothelioma tumors (MPM tumors).
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