pCDCAR1 ITGB3 h(FcεRIγ), T(CAR-T-1-L339-G)

The vector of anti-ITGB3 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human ITGB3. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-ITGB3 antibody linked to FcεRIγ signaling domains. And the vector product was designed for the treatment of chronic lymphoid leukemia.


Details


Target
ITGB3
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
Chronic lymphocyticleukemia (CLL)
Generation
First
Vector Name
pCDCAR1
Vector Length
8kb
Vector Type
Lentiviral
Receptor Construction
scFv-FcεRIγ
Discription of Signaling Cassetes
FcεRIγ
The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE). FcεRI is a key molecule involved in allergic reactions. It is a tetramer composed of 1alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The scFv-based CARs engineered to contain a signaling domain from FcεRIγ have been shown to deliver a potent signal for T cell activation and function.
Antibody Clone
PM6/13
Antibody Host
Mouse

Target


Gene Name
Integrin subunit beta 3
Official Symbol
ITGB3
Gene ID
Synonyms
ITGB3; integrin subunit beta 3; GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

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