Polyclonal CD3⁺ T Cell based Artificial T Cell Stimulator Development Service

Background

CD3 is a vital protein complex found on the surface of most T cells, acting as a coreceptor that facilitates their activation. This activation process is crucial for the expansion and function of both CD4+ helper T cells and CD8+ cytotoxic T cells, key players in the immune response against infections, cancer, and autoimmune diseases. By effectively activating CD3+ T cells, immunotherapy strategies aim to enhance the immune system's ability to combat these threats, offering promising avenues for clinical advancements.

Fig.1 Diagram depicting CD3+CD4-CD8- (Double-Negative) T cell origin and dissemination.^1,3

Polyclonal CD3+ T Cell based Artificial T Cell Stimulator Development Service at Creative Biolabs

Creative Biolabs provides a complete set of polyclonal CD3+ T cell-based artificial T cell stimulator development services, aiming to accelerate the development of CD3+ T cell immunotherapy. Our service covers the entire process from artificial T cell stimulator platform construction, T cell activation optimization to T cell function characterization. By adopting advanced cell engineering technology and a strict quality control system, we can quickly and efficiently build high-performance artificial T cell stimulators to achieve precise activation and expansion of polyclonal CD3+ T cells. In addition, we also provide customized experimental design and data analysis services to meet the personalized needs of our customers. Our goal is to work closely with our customers to jointly promote the clinical application of CD3+ T cell immunotherapy.

Attractive Features

• Comprehensive services: Our service covers all aspects of artificial T cell stimulator development, including platform construction, optimization, and characterization.
• High-quality assurance: We apply advanced technology and strict quality control to ensure smooth service and high-quality results.
• Efficient results delivery: We are confident in delivering customers' desired results in a short turnaround time.
• Customized services: We can personalize experimental design and data analysis to satisfy customers' various needs.

Data Display

This research seeks to clarify how human CD4+ T cells support the proliferation of CD8+ T cells through a newly established in vitro model. The team has designed a novel artificial T cell stimulator. Findings indicate that this artificial T cell stimulator can promote comprehensive expansion of CD3+ T cells without the need for allogeneic feeder cells. Additionally, the stimulation of CD3+ T cells with the artificial T cell stimulator leads to significant enhancement of CD8+ T cell proliferation.

Fig.2 Unbiased CD3+ T cell expansion stimulated by the engineered artificial T cell stimulator.^2,4

Associated Services

Creative Biolabs provides an extensive array of tailored artificial T cell stimulator development services, not only for polyclonal CD3+ T cells but also for various immune cell types. Our offerings encompass the customization of artificial T cell stimulators for CD4+ T cells, CD8+ T cells, CAR-T cells, NK cells, and more. This diverse range enhances our capability to support a broad spectrum of immunological research and therapeutic applications, ensuring that we meet the specific needs of our clients in advancing their projects.

• Antigen-Specific CD8+ T Cell based Artificial T Cell Stimulator Development Service
• Antigen-Specific CD4+ T Cell based Artificial T Cell Stimulator Development Service
• Chimeric Antigen Receptor Transduced T Cell based Artificial T Cell Stimulator Development Service
• Invariant Natural Killer T Cell based Artificial T Cell Stimulator Development Service
• Natural Killer Cell based Artificial T Cell Stimulator Development Service

Q & A

Q1: What are the typical steps involved in this service?

A1: Developing artificial T cell stimulators for polyclonal CD3+ T cell activation involves engineering platforms to express key molecules. This is followed by optimizing conditions to maximize T cell activation and expansion using these engineered artificial T cell stimulators. Finally, the activated T cells are rigorously characterized to assess their quality and functionality, including cytokine production and cytotoxic activity.

If you want to develop an ideal artificial T cell stimulator for stimulating CD3+ T cells, please click the link to reach out to us.

References

1. Wu, Zhiheng, et al. "CD3+ CD4-CD8-(Double-negative) T cells in inflammation, immune disorders and cancer." Frontiers in Immunology 13 (2022): 816005.
2. Butler, Marcus O., et al. "Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell help." PloS one 7.1 (2012): e30229.
3. Distributed under Open Access License CC BY 4.0, without modification.
4. Distributed under Open Access License CC BY, without modification.