CD47

CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 is a transmembrane glycoprotein expressed on all cells in the body and particularly overexpressed on cancer cells and cancer stem cells of both hematologic and solid malignancies. In the immune system, CD47 acts as a "don't eat me" signal, inhibiting phagocytosis by macrophages by interaction with signal regulatory protein α (SIRPα). In cancer, CD47 promotes tumor invasion and metastasis.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC364 T cell Third 5F9 ~8kb Lentiviral scFv (CD47)-CD28-41BB-CD3ζ/scFv (TAZ)-TET2 Mouse Inquiry
CAR-T-1-L344-2 T cell First B6H12.2 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-L344-G T cell First B6H12.2 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-L344-Z T cell First B6H12.2 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-L344-2G T cell Second B6H12.2 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-L344-2Z T cell Second B6H12.2 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-L344-4G T cell Second B6H12.2 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-L344-4Z T cell Second B6H12.2 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-L344-8Z T cell Second B6H12.2 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-L344-BZ T cell Second B6H12.2 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-L344-CZ T cell Second B6H12.2 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-L344-2BZ T cell Third B6H12.2 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-L344-2XZ T cell Third B6H12.2 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC121 B6H12.2 Lentivirus First scFv (B6H12.2)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC122 B6H12.2 Lentivirus First scFv (B6H12.2)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC123 B6H12.2 Lentivirus First scFv (B6H12.2)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC124 B6H12.2 Lentivirus Second scFv (B6H12.2)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC125 B6H12.2 Lentivirus Second scFv (B6H12.2)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC126 B6H12.2 Lentivirus Second scFv (B6H12.2)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC127 B6H12.2 Lentivirus Second scFv (B6H12.2)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC128 B6H12.2 Lentivirus Second scFv (B6H12.2)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC129 B6H12.2 Lentivirus Second scFv (B6H12.2)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC130 B6H12.2 Lentivirus Second scFv (B6H12.2)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC131 B6H12.2 Lentivirus Third scFv (B6H12.2)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC132 B6H12.2 Lentivirus Third scFv (B6H12.2)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

Distributors

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Australia
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