DMTF1

DMTF1 is a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer.

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-YC0012 T cell Second 1A8 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-YC0013 T cell Second 1B7 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-YC0540 T cell Second 11D62 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-YC0541 T cell Second 35K29 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-YC0542 T cell Second 5C6 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-YC0543 T cell Second 8C92 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-YC0544 T cell Second DMTF5I250 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-YC0912 T cell Second 1A8 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-YC0913 T cell Second 1B7 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-YC1440 T cell Second 11D62 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-YC1441 T cell Second 35K29 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-YC1442 T cell Second 5C6 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-YC1443 T cell Second 8C92 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-YC1444 T cell Second DMTF5I250 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry

DMAb Product list:

Catalog Target Target Species DMAb Host DMAb Cross Reactivity DMAb Clone Vector Name Data
sheet
Price
DMAb-012-YC DMTF1 Human Mouse Human 1A8 pVAX1 Inquiry
DMAb-013-YC DMTF1 Human Mouse Human 1B7 pVAX1 Inquiry
DMAb-540-YC DMTF1 Human Mouse Human 11D62 pVAX1 Inquiry
DMAb-541-YC DMTF1 Human Mouse Human 35K29 pVAX1 Inquiry
DMAb-542-YC DMTF1 Human Mouse Human 5C6 pVAX1 Inquiry
DMAb-543-YC DMTF1 Human Mouse Human 8C92 pVAX1 Inquiry
DMAb-544-YC DMTF1 Human Mouse Human DMTF5I250 pVAX1 Inquiry
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