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GNE

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The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-LY1274 Anti-GNE (CBLG1-2857) h(41BB-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human CBLG1-2857 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-LY1275 Anti-GNE (CBLG1-2858) h(41BB-CD3ζ) CAR, pCDCAR1 Rat, Human CBLG1-2858 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-LY2914 Anti-GNE(CBLG1-2857) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human CBLG1-2857 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-LY2915 Anti-GNE(CBLG1-2858) h(CD28-CD3ζ) CAR, pCDCAR1 Rat, Human CBLG1-2858 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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