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LCP2

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SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CQ1553 Anti-LCP2 (SLP-76/03) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Pig SLP-76/03 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1554 Anti-LCP2 (CBXS-3563) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-3563 Human scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1555 Anti-LCP2 (AS55) h(41BB-CD3ζ) CAR, pCDCAR1 Human AS55 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1556 Anti-LCP2 (CBXS-0038) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-0038 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1557 Anti-LCP2 (CBXS-0040) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Pig CBXS-0040 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1558 Anti-LCP2 (CBXS-1196) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-1196 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1559 Anti-LCP2 (CBXS-1458) h(41BB-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human CBXS-1458 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1560 Anti-LCP2 (CBXS-1465) h(41BB-CD3ζ) CAR, pCDCAR1 Rabbit, Human CBXS-1465 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1561 Anti-LCP2 (CBXS-1833) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-1833 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1562 Anti-LCP2 (CBXS-1936) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-1936 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1563 Anti-LCP2 (CBXS-3333) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Pig CBXS-3333 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4977 Anti-LCP2 (SLP-76/03) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse, Pig SLP-76/03 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4978 Anti-LCP2 (CBXS-3563) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXS-3563 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4979 Anti-LCP2 (AS55) h(CD28-CD3ζ) CAR, pCDCAR1 Human AS55 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4980 Anti-LCP2 (CBXS-0038) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXS-0038 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4981 Anti-LCP2 (CBXS-0040) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse, Pig CBXS-0040 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4982 Anti-LCP2 (CBXS-1196) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXS-1196 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4983 Anti-LCP2 (CBXS-1458) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human CBXS-1458 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4984 Anti-LCP2 (CBXS-1465) h(CD28-CD3ζ) CAR, pCDCAR1 Rabbit, Human CBXS-1465 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4985 Anti-LCP2 (CBXS-1833) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXS-1833 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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