MMP2

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

CAR Vector Products

CAT	Product Name	Target Species	Antibody Clone	Antibody Host	Receptor Construction	Vector Type	Targeting Cell Type	CAR Vector Type	Inquiry & Datasheet
XS-1222-ZP149	MMP2 (SDC2 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1	Human			MMP2-CD28-CD6ζ	Lentiviral vector	T cell		Add to Cart Datasheet
XS-1222-ZP1549	MMP2 (SDC2 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1	Human			MMP2-41BB-CD6ζ	Lentiviral vector	T cell		Add to Cart Datasheet

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MMP2

CAR Vector Products