VivoCAR™ Anti-CD123 (7G3) h(CD28-41BB-CD3z) CAR saRNA (XS-0326-XU94)

Name: VivoCAR™ Anti-CD123 (7G3) h(CD28-41BB-CD3z) CAR saRNA
SKU: XS-0326-XU94
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD123 (7G3) h(CD28-41BB-CD3z) CAR saRNA leverages the saRNA platform to express the 7G3 clone. In vivo, 7G3 is critical for its ability to block IL-3 signaling while simultaneously directing T cells to eliminate leukemic stem cells. The biological magnification of saRNA ensures that a minimal initial dose leads to high CAR levels in the bone marrow niche, effectively reprogramming T cells in situ to eradicate CD123-positive blasts in patients with refractory myeloid malignancies.

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CAR Information

Target
CD123

Target Species
Human

Antibody Clone
7G3

scFv Host Species
Human

Receptor Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation CD28-41BB-CD3ζ architecture employs a sequential costimulatory strategy, where the CD28 module drives rapid initial activation and metabolic reprogramming, while the 4-1BB component sustains long-term cellular viability and mitigates exhaustion. This tandem design, anchored by the CD3ζ signaling chain, synergistically amplifies downstream signal transduction, resulting in a balanced T-cell phenotype with robust effector capacity and prolonged durability. The integrated signaling cascade thus optimizes both kinetic expansion and persistence, enhancing antitumor efficacy.

CAR saRNA Properties

Structure
Linear

Cap
Cap 1

PolyA
Segmented PolyA

Product Type
CAR IVT saRNA

Concentration
Lot specific

Buffer
1 mM Sodium Citrate, pH 6.4 (or specialized RNA storage buffer, RNase-free).

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

saRNA Quality Control

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Target Information

Full Name
Cluster of Differentiation 123

Alternative Names
IL-3R-alpha; IL3RY; IL3RX; IL3RY; hIL-3Ra; IL3RA

Introduction
CD123 is the alpha subunit of the IL-3 receptor. It is highly expressed on leukemic stem cells and blasts in AML and BPDCN, but has low expression on normal hematopoietic stem cells, offering a significant therapeutic window.

Targeting Diseases
Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS), Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN), Chronic Myeloid Leukemia (CML)

UniProt ID
O75794

Gene ID
3563

Related Resources

Overview of CD123-Targeted CAR Cell Therapies

Case Studies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.