VivoCAR™ Anti-HIV-1 (PG9) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX19)

Name: VivoCAR™ Anti-HIV-1 (PG9) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX19
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-HIV-1 (PG9) h(CD28-41BB-CD3z) CAR circRNA features the potent PG9 clone, specifically chosen for its unique ability to recognize quaternary V1/V2 loop epitopes on the HIV-1 envelope trimer. This product is critical for in vivo applications where high-affinity recognition of the native viral spike is required to clear active infections. The circRNA architecture ensures superior resistance to RNA degradation, facilitating sustained CAR expression on endogenous lymphocytes. This approach provides a safe, non-viral method for achieving "functional cure" research by transiently empowering the host immune system to detect and destroy infected cells.

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Target Information

Target
HIV-1

Common Name
HIV-1

Alternative Names
HIV Envelope (Env)

Full Name
Human Immunodeficiency Virus Type 1

Introduction
HIV-1 Env is the viral surface glycoprotein trimer responsible for binding to CD4 receptors and facilitating viral entry. The CAR targets Env expressed on the surface of latently infected CD4+ T cells, with the goal of clearing the viral reservoir and achieving a functional cure for HIV infection.

Targeting Diseases
HIV infection (Functional Cure Strategy)

UniProt ID
P05877

Gene ID
155971

CAR Information

Target Species
Human

Antibody Clone
PG9

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

CAR circRNA Properties

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

circRNA Properties and Quality Control

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Case Studies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.