VivoCAR™ Anti-GPRC5D (2A4) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX123)

Name: VivoCAR™ Anti-GPRC5D (2A4) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX123
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-GPRC5D (2A4) h(CD28-41BB-CD3z) CAR circRNA utilizes the 2A4 clone to target GPRC5D, a lineage-specific surface receptor highly prevalent in multiple myeloma. The significance of the 2A4 clone for in vivo applications lies in its capacity to identify malignant plasma cells with exceptional specificity, effectively bypassing common B-cell antigens. By utilizing the circRNA platform, this product generates a transient surge of CAR activity that concentrates the immune response within the bone marrow niche. This approach minimizes the risk of prolonged cytopenia and allows for the controlled, non-permanent eradication of myeloma cells.

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Target Information

Target
GPRC5D

Common Name
GPRC5D

Alternative Names
G-protein coupled receptor class C group 5 member D

Full Name
G Protein-Coupled Receptor Class C Group 5 Member D

Introduction
GPRC5D is a highly restricted G-protein-coupled receptor characterized by seven transmembrane domains. It exhibits dense and specific expression on the surface of malignant plasma cells in Multiple Myeloma (MM), while its presence in healthy tissues is strictly localized to hard keratinized structures, such as hair follicles. This distinct expression pattern establishes it as an ideal "next-generation" target for MM, particularly for patients who have relapsed following BCMA-targeted therapies, given that GPRC5D and BCMA are expressed independently of one another.

Targeting Diseases
Multiple Myeloma (MM), Plasma Cell Leukemia

UniProt ID
Q9NZD1

Gene ID
2719

Target Species
Human

Antibody Clone
2A4

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-GPRC5D (2A4) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX123)

Target Information

Customer Reviews and Q&As

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