VivoCAR™ Anti-IL1RAP (IAPB63) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX94)

Name: VivoCAR™ Anti-IL1RAP (IAPB63) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX94
Rating: 5 (1 reviews)

Online Inquiry Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-IL1RAP (IAPB63) h(CD28-41BB-CD3z) CAR circRNA leverages the IAPB63 clone, optimized for its robust binding in the inflammatory microenvironment of acute myeloid leukemia (AML). This clone is vital for its ability to trigger potent cytolytic signaling upon identifying IL1RAP+ blasts. The circular RNA scaffold ensures a durable translation window for the CAR protein on circulating T cells, facilitating a systemic search-and-destroy mission against aggressive myeloid lineages. This approach offers a repeatable, safe strategy that naturally tapers off, protecting the host's normal immune homeostatic functions.

Add to Cart

Target Information

Target
IL1RAP

Common Name
IL1RAP

Alternative Names
C3orf13, IL-1RAcP, IL1R3

Full Name
Interleukin-1 Receptor Accessory Protein

Introduction
IL1RAP is a critical component of the IL-1 receptor complex, essential for signal transduction. While broadly expressed at low levels, it is highly and selectively overexpressed on various cancer stem cells (CSCs) and malignant progenitor cells, particularly in Acute Myeloid Leukemia (AML). Its high expression on AML\CSCs and its limited expression on normal hematopoietic stem cells make it an attractive target for eradicating the root of the leukemia without causing severe myelosuppression.

Targeting Diseases
Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS), Chronic Myeloid Leukemia (CML), Some Solid Tumors

UniProt ID
Q9NPH3

Gene ID
3556

Target Species
Human

Antibody Clone
IAPB63

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Customer Reviews and Q&As

There are currently no customer reviews or questions for VivoCAR™ Anti-IL1RAP (IAPB63) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX94). Click the button below to contact us or submit your feedback about this product.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.