EB1 Pep-LNP

Cat. No.: TDLD-0825-LD99

EB1 Pep-LNP

EB1 Pep-LNP is a state-of-the-art peptide-functionalized lipid nanoparticle (LNP), designed for efficient targeted delivery of therapeutic cargoes such as siRNA, mRNA, DNA, small molecule drugs, and RNA-guided gene editing systems. Engineered with the EB1 peptide, a pH-responsive transmembrane peptide that exhibits enhanced cell membrane penetration capabilities under acidic conditions, this LNP facilitates the efficient internalization and delivery of the therapeutic payload into target cells, particularly those within acidic microenvironments like tumors or endosomes. Our LNP is prepared using DSPE-PEG-EB1 and a variety of optional lipid formulations including DLin-MC3-DMA, LP-01, ALC-0315, SM102, and others. These formulations are carefully selected to ensure the LNP has uniform particle size, high encapsulation efficiency, stability, and targeted delivery. Applications of EB1 Pep-LNP include targeted therapy for pH-sensitive tumors, developing efficient intracellular delivery platforms for nucleic acids or drugs, studying endosomal escape mechanisms, and evaluating novel strategies for overcoming cellular uptake barriers. Please note that this product is intended for research purposes only.